tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

Collaborative research by the University of Tokyo and RIKEN Center for Biosystems Dynamics Research has led to the development of a new method for simultaneously synthesizing all transfer RNA (tRNA) ...

RNA therapeutics target translation rather than DNA, aiming to correct shared protein production errors. By enabling cells to read through premature stop codons, engineered tRNAs could restore ...

The ribosome, that protein-making machine, relies on other, smaller machines. For example, it works in concert with a mechanism that supplies amino-acid-carrying tRNAs, including tRNAs that require ...

Loss of TRMT10A led to a decrease in the levels of initiator methionine tRNA (tRNA iMet) and a specific glutamine tRNA (tRNA Gln). This reduction weakened the initiation of protein synthesis for ...

The synthesis of archaeosine involves multiple steps, with the first step introducing a preQ 0 base into tRNA via ArcTGT. In the second step, ArcS transfers an amino acid, lysine, to the preQ 0 base ...

EXPORT MECHANISM: The tRNA must mature inside the nucleus before export. tRNAs are aminoacylated, and only tRNAs charged with an amino acid are exported efficiently. Export occurs when the tRNA is ...

During protein synthesis, the genetic information stored in DNA is first transcribed into mRNA. The mRNA then travels to the ribosome, where translation occurs. Here's how anticodons facilitate the ...

A novel tRNA fragment limits UV-driven photoageing by protecting collagen and mRNA stability. Discover the mechanism and its therapeutic potential. Read more.